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KMID : 0367420040470090965
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Journal of Korean Pediatric Society
2004 Volume.47 No. 9 p.965 ~ p.969
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Effects of the Chronic Use of Anticonvulsants on Bone Mineral Density in Children with Epilepsy.
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Oh Hyun-Hee
Jang You-Cheol
Choe Byung-Ho
Park Il-Hyung
Kwon Soon-Hak
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Abstract
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Purpose : Chronic administration of anticonvulsants for children with epilepsy may cause multiple
abnormalities in bone metabolism. The aim of this study was to evaluate the effects of anticonvulsants
on bone mineral density(BMD) in children with epilepsy.
Methods : Seventy patients with epilepsy were enrolled in this study. All subjects had taken
anticonvulsants for at least 1 year or more. Subjects were classified into three groups according to
age(5-7 yrs, 8-11 yrs, >12 yrs). BMD was measured by Dual-energy X-ray Absorptiometry(DXA)
on the lumbar spine and whole body. Statistical analysis for BMD of anticonvulsants-treated subjects
were compared to results with the published data.
Results : BMD was significantly decreased in the anticonvulsants-treated group as compared with
the control group of all age groups(P<0.05). But BMD among groups according to anticonvulsants
was not significantly different(P>0.05).
Conclusion : Because chronic administration of anticonvulsants for growing children leads to a decrease
in BMD, early detection and management of abnormal BMD is important in monitoring of
children with epilepsy. (Korean J Pediatr 2004;47:965-969)
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KEYWORD
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Anticonvulsants, Bone density, Child
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